![]() ![]() Among the age- and sex-matched cohort, the mean (SD) age was 52.3 (15.1) years and 41.2% (47 of 114) were male. MAIN OUTCOMES AND MEASURES The diagnostic performance of the FIB-4 and NFS at the current cutoff for advanced hepatic fibrosis in lean (body mass index below 23 ) and nonlean (BMI above 23) patients were evaluated. All statistical analyses were executed from October 2022 to March 2023. Cohorts were matched by age and sex between the lean and nonlean groups. ![]() OBJECTIVE To evaluate the diagnostic performance of the FIB-4 and NFS in lean individuals with NAFLD.ĭESIGN, SETTING, AND PARTICIPANTS This diagnostic study included adults with biopsy-proven NAFLD from 6 referral centers in Asia from 1995 to 2019. IMPORTANCE The diagnostic performance of the fibrosis-4 index (FIB-4) and nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) for advanced fibrosis in lean patients with NAFLD is limited. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment. ![]()
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